PROGRAM
Adaptive designs? Adaptive randomization? (9h15 – 12h30)
- 9h15 – 9h50 Franz König (Medical University Vienna, Austria): Confirmatory adaptive designs
- 9h50 – 10h25 Thomas Jaki (Lancaster University, UK): Flexible sequential designs for multi-arm clinical trials.
Pause 10h25 – 10h55
- 10h55 – 11h30 Bill Barry (Dana Farber Medical Center, Boston, USA): Platform trials and the use of Bayesian hierarchical models for adaptive randomization in biomarker-driven studies.
- 11h30 – 12h30 Round table on adaptive trials and adaptive randomization (F König, T Jaki, B Barry, S Senn, M Resche-Rigon, L Collette) chaired by S Michiels and X Paoletti
Introduction by Xavier Paoletti (INSERM OncoStat & Gustave Roussy, Villejuif, France)
Lunch 12h30 – 13h30
Beyond standard inference in survival analyses after design deviations (13h30 – 16h30)
- 13h30 – 14h05 Stephen Senn (Luxembourg Institute of Health, Luxembourg): Simplicity, complexity and modelling in clinical trials
- 14h05 – 14h40 Mathieu Resche-Rigon (CHU St Louis & INSERM ECSTRA, Paris, France ): Adjusting for treatment by center interaction
Pause 14h40 - 15h00
- 15h00 – 15h35 Ian White (Medical Research Council Clinical Trials Unit at UCL, London, UK): Treatment changes in cancer clinical trials: design and analysis
- 15h35 – 16h10 Mohamed Amine Bayar (INSERM OncoStat & Gustave Roussy, Villejuif, France): Interim analysis and treatment selection in time-to-event randomized trials in rare diseases on a long-term horizon
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